Metabolic Changes Linked to Abuse and Depression

A pilot study conducted at the University of Eastern Finland found metabolites related to oxidative stress and the transsulfuration pathway of one-carbon metabolism to be associated with a history of sexual or physical abuse in depressed adolescent outpatients. Oxidative stress and transsulfuration are closely connected and regulate each other’s functions, and they play a role in inflammation, which is also recognized as a possible mechanism of trauma.