Midlife Brain Remodel: Immune Shifts and Genome Reorganization in Aging Hippocampus
TL;DR
A single-cell study of the aging human hippocampus shows midlife immune shifts from embryonically derived microglia to inflammatory blood-like cells, loss of blood-brain barrier cells, and widespread remodeling of genome architecture across brain cell types, suggesting aging is an active, coordinated remodeling process linked to neurodegenerative risk and revealing potential therapeutic targets.
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