Mescaline Dampens the Brain’s Gatekeeper, Hinting at Hallucinations

Northeastern researchers using MRI in rodents show mescaline uniquely dampens the cerebellum—the brain’s sensory filter—while increasing cross-brain connectivity, potentially driving hallucinatory experiences and linking to sensory-disruption seen in some psychiatric conditions; findings differ from LSD/psilocybin and point to translational steps toward human studies and clinical relevance.