A Longevity Variant Protects Brain DNA, Reducing Alzheimer's Risk, Study Finds
TL;DR
Buck Institute researchers find that the APOE2 gene variant helps neurons resist DNA damage and cellular aging, which may explain the lower Alzheimer's risk. In stem-cell–derived neurons and mice, APOE2-expressing cells showed less DNA damage, better repair, and resistance to senescence, and APOE2 protein could shield APOE4 neurons as well, suggesting new therapeutic avenues—though exact mechanisms are still unknown and the study used stress-induced conditions.
- This Gene Is Linked to Lower Alzheimer's Risk – And We May Finally Know Why ScienceAlert
- 'Longevity gene' may protect the brain from Alzheimer's by boosting DNA repair, study finds Fox News
- Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer’s disease | Nature Aging Nature
- Longevity-linked APOE2 gene variant helps neurons repair DNA and resist aging Medical Xpress
- This “Longevity Gene” May Protect the Brain From Aging and Dementia SciTechDaily
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