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Apoe

All articles tagged with #apoe

New Neuronal IDOL Target Could Cut Alzheimer's Plaque Burden
science15 days ago

New Neuronal IDOL Target Could Cut Alzheimer's Plaque Burden

Researchers at Indiana University identified neuronal IDOL as a new drug target for Alzheimer’s, showing that reducing IDOL activity in brain neurons lowers amyloid plaques and APOE levels, while boosting receptors that regulate APOE and amyloid. The neuron-focused approach produced stronger effects than targeting microglia, suggesting a potential multi-benefit therapy. Next steps include preclinical safety testing and evaluating whether IDOL blockade preserves synapses and reduces tau pathology.

via SciTechDaily|
#alzheimers-disease#amyloid-plaques#apoe
Meat-Rich Diet Linked to Lower Dementia Risk in Certain Gene Carriers
health17 days ago

Meat-Rich Diet Linked to Lower Dementia Risk in Certain Gene Carriers

A Swedish study followed about 2,100 seniors for up to 15 years and found that among APOE 3/4 or 4/4 carriers, higher meat intake was associated with slower cognitive decline and a lower risk of dementia, with unprocessed meat driving the benefit; those with the genetic risk who ate more meat had reduced risk compared with those who ate less, though the study is observational and researchers call for trials to tailor dietary guidance by APOE genotype.

via Good News Network|
#apoe#dementia#diet
APOE Variants Could Drive the Majority of Alzheimer's Risk, Study Finds
health2 months ago

APOE Variants Could Drive the Majority of Alzheimer's Risk, Study Finds

A large analysis of about 470,000 people shows that the APOE gene, especially the ε3 and ε4 variants, accounts for most Alzheimer's risk, with ε3 not being neutral and ε2 offering protection. The findings imply APOE-focused therapies could prevent or reduce many cases, though translating this into treatments will be complex and lifestyle factors also influence risk; roughly half of dementia risk could be linked to APOE variations.

via ScienceAlert|
#alzheimers-disease#apoe#apoe-e3e4
science1 year ago

APOE Variants: How Receptors and Lysosomes Influence Risk

A recent study published in Cell reveals that the risk of late-onset Alzheimer's disease associated with different APOE gene variants is linked to lysosomal dysfunction. Researchers found that the high-risk ApoE4 variant, unlike the protective ApoE2 and Christchurch variants, transports lipids into lysosomes, leading to the accumulation of lipofuscin, a toxic byproduct. This process is exacerbated by the strong binding of ApoE4 to low-density lipoprotein receptors, causing increased lipid uptake and oxidative stress in lysosomes. These findings offer new insights into the molecular mechanisms of Alzheimer's and potential therapeutic targets.

via Alzforum|
#alzheimers#apoe#genetics
"Breakthroughs in Alzheimer's Research: Discoveries in Risk Genes and Promising Treatments"
neuroscience3 years ago

"Breakthroughs in Alzheimer's Research: Discoveries in Risk Genes and Promising Treatments"

Researchers have discovered a connection between the most common form of Alzheimer's disease (sAD) and a rarer form (fAD), shedding light on how the two types are linked. The study found that abnormal γ-cleavage of amyloid precursor protein (APP) is the common pathogenic cause of both types of Alzheimer's. The researchers also discovered that different variants of the ApoE gene can significantly impact the risk of developing sAD, with ApoE2 showing the strongest inhibitory activity on γ-cleavage of APP. This finding could help researchers develop new treatments for Alzheimer's.

via Neuroscience News|
#alzheimers-disease#amyloid-plaques#apoe