Autism Shows Two Distinct Brain Connectivity Subtypes Across Species

An international study analyzing mouse models and human brain scans identified two autism subtypes—hypoconnectivity (reduced connectivity linked to synapse genes) and hyperconnectivity (increased connectivity linked to immune-related genes)—a finding replicated across datasets that could guide subtype-specific therapies, with data and methods openly shared for future research; about a quarter of the human brains fell into these groups, signaling a move toward biologically grounded stratification beyond a single-spectrum view.