Blood Clues Map Organ-Specific Biological Ages

TL;DR Summary
A Nature Medicine study trained AI on 25,712 tissue images from 983 donors to create organ-specific 'tissue clocks' that judge whether an organ looks older or younger than expected; a blood-based model then predicts these age gaps from gene activity, with larger gaps linked to conditions like stroke, Crohn's disease, and Alzheimer's. The approach is not yet clinical, faces limitations (mostly post-mortem samples, non-prospective data) and would require years to regulatory approval.
- A Single Blood Sample May Reveal The Biological Age of Each of Your Organs ScienceAlert
- Tony Wyss-Coray Is Measuring Biological Age One Organ at a Time Time Magazine
- Histological aging signatures for monitoring tissue-specific aging and disease Nature
- A single blood test could offer a glimpse of disease risk years in advance News-Medical
- Cell Ageing Clocks From Blood Predict Alzheimer’s, ALS Zenopa
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