Cancer Protein May Unlock a New Avenue for Alzheimer’s Treatment
TL;DR
In a mouse study, tumors produced the protein cystatin-C, which traveled to the brain, bound toxic amyloid oligomers, and activated microglia via the TREM2 receptor to clear plaques, improving cognitive tasks. While promising as a novel research path beyond amyloid-lowering strategies, whether these effects translate to humans remains unknown and more work is needed; the study warns against pursuing cancer as a therapy and emphasizes early-stage findings.
- What If Cancer Holds the Key to New Treatments for Alzheimer’s Disease? Gizmodo
- Cancer tumors may protect against Alzheimer's by cleaning out protein clumps Medical Xpress
- Study Uncovers a Possible Explanation for Why Cancer and Alzheimer's Disease Rarely Occur in the Same Individuals Labroots
- Scientists Explore Cancer's Connection to Alzheimer's Disease insidehook.com
- Protein from cancer cells clears Alzheimer's plaques in mice 동아사이언스
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