Could Alzheimer’s Pathology Be Transmitted Through Blood Transfusions?

A Lancet review explores whether amyloid-beta pathology linked to Alzheimer’s could spread via blood transfusions. While not proven, prior work hints at transferable amyloid via medical procedures, and a 2023 Danish-Swedish study found recipients of transfusions from donors who later developed brain bleeds had higher recurrence risk, a clue connected to cerebral amyloid angiopathy. Experts urge caution, noting insufficient data to quantify risk, but advocate large-scale epidemiological studies and potential safeguards (donor biomarker screening, enhanced monitoring for high-risk patients). The UK infected blood inquiry is cited as a cautionary example of delaying safety measures, underscoring the need for transparency and preparedness.