EPA-heavy fish oil may hinder brain repair after repeated head injuries

A Cell Reports study in mice and human brain endothelial cells found that long-term fish oil supplementation high in EPA may reduce brain repair capacity and promote tau accumulation after repeated mild TBIs, while DHA showed no similar effect. The results suggest context-dependent effects of omega-3s on brain healing and are not yet proven in humans; individuals with a history of repeated head injuries should discuss fish oil use with a clinician.