Fat-Cell Gatekeeper HSL Reveals Hidden Role in Adipose Health
TL;DR Summary
Researchers found that hormone-sensitive lipase, long viewed solely as a fat-mobilizing enzyme, also enters the nucleus of fat cells to regulate adipose tissue health. This nuclear role helps explain why HSL deficiency leads to lipodystrophy and how fat-tissue dysfunction links obesity with metabolic disease, potentially opening new paths to treat obesity by targeting fat-cell health rather than weight alone.
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