All articles tagged with #adipose tissue
Researchers found that hormone-sensitive lipase, long viewed solely as a fat-mobilizing enzyme, also enters the nucleus of fat cells to regulate adipose tissue health. This nuclear role helps explain why HSL deficiency leads to lipodystrophy and how fat-tissue dysfunction links obesity with metabolic disease, potentially opening new paths to treat obesity by targeting fat-cell health rather than weight alone.
Scientists found that hormone-sensitive lipase (HSL), long known for releasing fat, also operates inside the nucleus of fat cells to maintain healthy adipose tissue and regulate metabolic processes. Loss of this nuclear HSL leads to lipodystrophy rather than obesity, helping explain why fat quality matters and suggesting obesity therapies should aim to preserve fat‑cell function, not just reduce fat mass.
New research links fat tissue dysfunction to metabolic disease, showing that both excess fat and losing fat improperly disrupt lipid storage, trigger inflammation and mitochondrial dysfunction, and raise risks of diabetes and fatty liver, highlighting therapies that protect or restore adipose tissue.
Fat is not just storage: brown fat burns calories to generate heat, beige fat can arise within white fat, and both offer targets for obesity therapies. The next generation of treatments may combine GLP-1–based appetite suppression with methods to boost energy expenditure across fat, muscle, and liver, aiming for more durable weight loss while avoiding hunger-driven compensation. This reframes fat as a dynamic metabolic organ and points to a multi-tissue, precision approach to energy balance.
This study provides a comprehensive single-cell epigenomic atlas of human subcutaneous adipose tissue, revealing cell-type-specific DNA methylation, chromatin conformation, and gene expression patterns, and their implications for obesity-related genetic risks and regulatory mechanisms.
A study conducted by researchers at the University of Girona in Spain has found that adipose tissue (fat tissue) plays a role in co-regulating cognitive function. The study identified 188 genes associated with cognitive performance through RNA sequencing of adipose tissue in three patient cohorts. These genes were linked to synaptic function, anti-inflammatory signaling, vitamin metabolism, phosphatidylinositol metabolism, and the complement cascade. The researchers also found that targeted misexpression of candidate genes in fruit flies and mice significantly altered memory and learning. The study provides insights into the adipose-brain axis and potential diagnostic and therapeutic targets in adipose tissue.