Garlic-Derived Compound May Enhance Muscle Health by Fat-Brain Signaling

Scientists in Japan identified S-1-propenyl-L-cysteine (S1PC) in aged garlic extract that activates liver kinase B1 (LKB1) and promotes adipose-derived eNAMPT secretion; the eNAMPT-containing vesicles travel to the hypothalamus to boost sympathetic signaling and improve muscle function, with aged mice showing reduced frailty and stronger muscles and human data showing higher eNAMPT levels on S1PC, suggesting a potential safe nutraceutical to counter age-related muscle decline—pending further study.