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Genes Partly Predict Response to GLP-1 Weight-Loss Shots

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Source: The Guardian
Genes Partly Predict Response to GLP-1 Weight-Loss Shots
Photo: The Guardian
TL;DR

Scientists analyzed data from 27,885 patients taking GLP-1 obesity drugs and found two gut-hormone gene variants may partly explain why weight loss and side-effects vary: rs10305420 is linked to slightly more weight loss, while rs1800437 is linked to nausea with tirzepatide. But the genetic contribution is modest; non-genetic factors like sex, drug type, dose, and duration explain much more of the variability, so genetics are not yet ready to guide routine treatment, though the findings could inform future precision approaches.

Topics:healthscience#genetics#glp1#obesity#pharmacogenomics#science#weight-loss-drugs
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  1. Genetics may help explain why results from weight-loss jabs vary, say scientists  The Guardian
  2. Genetic predictors of GLP1 receptor agonist weight loss and side effects  Nature
  3. If you aren’t losing weight with GLP-1 drugs, this may be one reason why  The Washington Post
  4. Weight-loss drugs: Who benefits most and why?  BBC
  5. How well GLP-1 weight loss drugs work may depend on your genetics  Scientific American

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