Tag

Pharmacogenomics

All articles tagged with #pharmacogenomics

health3 days ago•5 min saved

Genes help explain why obesity drugs work differently for people

Nature reports a study of nearly 28,000 23andMe users who used obesity drugs, linking a GLP-1 receptor gene variant to greater weight loss (about 0.76 kg per copy, ~1.5 kg for two copies) over a median of 8 months, and other variants to higher risk of side effects like nausea. Overall genetic effects on weight loss are modest, but associations with adverse effects are stronger; findings come from self-reported data and are not yet ready to guide clinical practice.

via Nature|

#23andme #genetics #glp-1

science3 days ago•2 min saved

Genes Partly Predict Response to GLP-1 Weight-Loss Shots

Scientists analyzed data from 27,885 patients taking GLP-1 obesity drugs and found two gut-hormone gene variants may partly explain why weight loss and side-effects vary: rs10305420 is linked to slightly more weight loss, while rs1800437 is linked to nausea with tirzepatide. But the genetic contribution is modest; non-genetic factors like sex, drug type, dose, and duration explain much more of the variability, so genetics are not yet ready to guide routine treatment, though the findings could inform future precision approaches.

via The Guardian|

#genetics #glp1 #obesity