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Genetic variants forecast GLP-1 weight‑loss response and nausea risk

1 min read
Source: Nature
Genetic variants forecast GLP-1 weight‑loss response and nausea risk
Photo: Nature
TL;DR Summary

A large GWAS in 23andMe participants identifies a GLP1R missense variant (rs10305420) linked to greater weight loss from GLP‑1 receptor agonists (~0.76 kg per allele) and links GLP1R and GIPR variants to treatment‑related nausea/vomiting, with a tirzepatide‑specific GIPR signal; replication in All of Us EHR data and integrated predictive models show that combining genetic and non‑genetic factors can stratify patients by efficacy and side‑effect risk, advancing precision obesity treatment.

Topics:health#gipr#glp1r#obesity#pharmacogenetics#science#tirzepatide
Share this article
  1. Genetic predictors of GLP1 receptor agonist weight loss and side effects  Nature
  2. New light shed on who benefits most from weight-loss jabs  BBC
  3. If you aren’t losing weight with GLP-1 drugs, this may be one reason why  The Washington Post
  4. Genetics may help explain why results from weight-loss jabs vary, say scientists  The Guardian
  5. How well GLP-1 weight loss drugs work may depend on your genetics  Scientific American

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