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Glp1r

All articles tagged with #glp1r

Genetic variants forecast GLP-1 weight‑loss response and nausea risk
science3 days ago

Genetic variants forecast GLP-1 weight‑loss response and nausea risk

A large GWAS in 23andMe participants identifies a GLP1R missense variant (rs10305420) linked to greater weight loss from GLP‑1 receptor agonists (~0.76 kg per allele) and links GLP1R and GIPR variants to treatment‑related nausea/vomiting, with a tirzepatide‑specific GIPR signal; replication in All of Us EHR data and integrated predictive models show that combining genetic and non‑genetic factors can stratify patients by efficacy and side‑effect risk, advancing precision obesity treatment.

via Nature|
#gipr#glp1r#obesity
New Imaging Techniques Uncover How Dual Agonist Drugs Target Brain and Pancreas for Diabetes and Obesity
science7 months ago

New Imaging Techniques Uncover How Dual Agonist Drugs Target Brain and Pancreas for Diabetes and Obesity

The article discusses the development of fluorescent probes, daLUXendin544 and daLUXendin660, which specifically target GLP1R and GIPR receptors in the pancreas and brain, enabling detailed visualization of cell targets and receptor nanodomains, and providing insights into the cellular mechanisms of dual agonists like tirzepatide for diabetes and obesity treatment.

via Nature|
#dual-agonist#gipr#glp1r