Hypoxia reverses a proteostasis-linked mitochondrial disease via HTRA2-CLPB axis
TL;DR
Reducing oxygen levels (hypoxia) can rescue a mitochondrial disease driven by proteostasis defects linked to the HTRA2–CLPB axis, extending oxygen-based therapy concepts beyond primary respiratory chain mutations.
Topics:healthscience#complex-i-dysfunction#htra2-clpb-axis#hypoxia#mitochondria#proteostasis#science
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