Knee relief breakthrough, room-temperature superconductivity, and cosmic enigmas this week

This This Week in Science roundup covers six stories: a minimally invasive knee treatment using dissolvable gel beads that block new nerve growth to OA pain, potentially halving knee pain over a year; a new world record for superconductivity at ambient pressure and higher temperatures; two patients with severe autoimmune disease achieving remission after alloHCT (donor stem cell reboot of the immune system); JWST-detected a mysterious chemical signature on Pluto and Titan; a lab analog simulating Hawking radiation backreaction in a black-hole-like system; and evidence that a fast-mimicking diet may reduce gum disease-related inflammation, highlighting links between diet, inflammation, and oral health. Watch the TWIS video recap for highlights.