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Immune System Reset

All articles tagged with #immune system reset

Knee relief breakthrough, room-temperature superconductivity, and cosmic enigmas this week
science9 days ago

Knee relief breakthrough, room-temperature superconductivity, and cosmic enigmas this week

This This Week in Science roundup covers six stories: a minimally invasive knee treatment using dissolvable gel beads that block new nerve growth to OA pain, potentially halving knee pain over a year; a new world record for superconductivity at ambient pressure and higher temperatures; two patients with severe autoimmune disease achieving remission after alloHCT (donor stem cell reboot of the immune system); JWST-detected a mysterious chemical signature on Pluto and Titan; a lab analog simulating Hawking radiation backreaction in a black-hole-like system; and evidence that a fast-mimicking diet may reduce gum disease-related inflammation, highlighting links between diet, inflammation, and oral health. Watch the TWIS video recap for highlights.

Georgia Woman Becomes State’s First HALT Transplant Recipient, Saving Her Failing Heart
health9 days ago

Georgia Woman Becomes State’s First HALT Transplant Recipient, Saving Her Failing Heart

Monica McFarlan, diagnosed with heart failure at 37, endured years of surgeries and LVADs and was deemed ineligible for a traditional heart transplant due to high antibodies. In a groundbreaking 16-hour Heart-After-Liver Transplant (HALT), doctors first transplant a liver to reset her immune system, then perform the heart transplant, making her the first patient in Georgia to receive this treatment and giving her a life-saving second chance while she remains on lifelong immunosuppression.

Stem-Cell Immune Reset Sparks Long-Term Remission in Two NMO Patients
health16 days ago

Stem-Cell Immune Reset Sparks Long-Term Remission in Two NMO Patients

Two 28-year-old patients with severe neuromyelitis optica achieved relapse-free, treatment-free remission for 15–16 years after allogeneic hematopoietic cell transplantation (donor stem-cell transplant) that rebooted their immune systems; one now leads a normal life and has children, the other reports good quality of life with reduced disability. While the approach shows promise, it carries substantial risk and was performed in carefully selected, treatment-refractory cases; larger studies are needed to confirm safety and determine broader applicability.

Hybrid Immune Transplants Reverse Type 1 Diabetes in Mice
health4 months ago

Hybrid Immune Transplants Reverse Type 1 Diabetes in Mice

Stanford researchers show that in mice, a combined transplant of donor blood stem cells and mismatched pancreatic islet cells can restore insulin production and retrain the immune system, curing or preventing autoimmune Type 1 diabetes without immunosuppressants or graft-versus-host disease for at least six months, using CD117 antibody–based conditioning to create a hybrid immune system and a path toward human translation (with challenges like donor islet availability).