New Intraneuronal Mitochondrial Plaques May Drive Early Alzheimer's

Researchers identify mitochondrial plaques—intracellular, mitochondria-based accumulations rich in APP—that form in neurons during early Alzheimer’s, before traditional extracellular beta-amyloid plaques, and often later co-localize with them. This discovery suggests a new early driver of neurodegeneration and a potential therapeutic target, with next steps including biomarker development and drug screening to block their formation.