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Amyloid Precursor Protein

All articles tagged with #amyloid precursor protein

science2 hours ago•5 min saved

New Intraneuronal Mitochondrial Plaques May Drive Early Alzheimer's

Researchers identify mitochondrial plaques—intracellular, mitochondria-based accumulations rich in APP—that form in neurons during early Alzheimer’s, before traditional extracellular beta-amyloid plaques, and often later co-localize with them. This discovery suggests a new early driver of neurodegeneration and a potential therapeutic target, with next steps including biomarker development and drug screening to block their formation.

via Neuroscience News|

#alzheimers-disease #amyloid-precursor-protein #early-stage-disease

health3 years ago•4 min saved

Embryonic Origins of Alzheimer's Disease Suggested by Stem Cell Model.

A recent study has found that the amyloid precursor protein (APP) plays a significant role in regulating human brain development and the timing of neurogenesis. The absence of APP leads to rapid neuron production, suggesting a potential link between human neurogenesis timing and neurodegenerative diseases like Alzheimer's. This could point to early vulnerabilities leading to neurodegeneration later in life. The study could potentially link the timing of human neurogenesis to mechanisms of neurodegenerative diseases like Alzheimer’s, suggesting that abnormalities in APP expression may result in a brain that functions normally at birth but is more susceptible to neurodegeneration later in life.

via SciTechDaily|

#alzheimers-disease #amyloid-precursor-protein #brain-development

neuroscience3 years ago•5 min saved

The Link Between Neurodevelopment and Alzheimer's Disease

Researchers have found that the amyloid precursor protein (APP) regulates the timing of neurogenesis in humans, and abnormalities in APP could cause premature neurogenesis and increased cellular stress, potentially setting the stage for Alzheimer’s disease later in life. The study suggests that neurodegenerative diseases might have origins in early neurodevelopmental disruptions, potentially exacerbated by lifestyle and environmental factors over time. The findings could lead to a better understanding of the mechanisms behind Alzheimer's disease and other neurodegenerative disorders.

via Neuroscience News|

#alzheimers-disease #amyloid-precursor-protein #brain-development