Omega-3 Supplements Could Accelerate Cognitive Decline in APOE ε4 Carriers, Study Suggests

An observational analysis of the ADNI cohort (800+ older adults, about half APOE ε4 carriers) found that those taking omega-3 supplements showed faster cognitive decline on MMSE and related tests than non-users, with no clear link to Alzheimer's brain biomarkers; the researchers caution that this is not causal and the sample isn’t representative, highlighting a need for nuanced, dose- and context-dependent research. While some reviews hint at low-dose benefits, high doses might be harmful, suggesting omega-3 should be approached with care and preferably sourced from whole foods until more evidence clarifies its brain effects.