One-carbon metabolism orchestrates multi-tissue metabolic reprogramming in cancer cachexia

Multi-omics profiling across eight tissues in cachexia-bearing mice reveals a coordinated metabolic shift centered on one-carbon metabolism, linked to inflammation, glucose hypermetabolism and muscle atrophy; the pattern recapitulates across five cancer models and a humanized cachexia model, offering a systemic framework for tumor–host metabolic reprogramming and potential intervention targets.