All articles tagged with #multi omics
A new perspective in Nature Communications argues that the primary bottleneck in microbiome research has shifted from data generation to reproducible interpretation. Authors propose a collaborative roadmap to standardize experimental design, metadata, and computational workflows to ensure that multi-omics studies yield meaningful biological insights rather than just increased data volume.
A large, longitudinal study of 1,154 hospitalized COVID-19 patients using multi-omic analyses found significant reactivation of chronic viruses, especially Herpesviridae (EBV, CMV, HSV) and Anelloviridae, during acute illness with distinct timing for different viruses. Reactivation correlated with greater disease severity and adverse outcomes and persisted into convalescence, with Anelloviridae associated with long COVID. Although causality isn’t established, the results show frequent viral reactivation in immunocompetent patients during severe illness and reveal immune, transcriptomic, and metabolic changes linked to reactivation, offering potential prognostic and therapeutic insights for acute COVID-19 and long COVID.
A Stanford-led study analyzing 135,000 molecular markers in 108 people finds aging may occur at two discrete inflection points—around ages 44 and 60—where rapid changes occur in cardiovascular, immune, and metabolic pathways, with microbiome shifts closely linked to these transitions. While causality isn’t established, the results suggest midlife biology could influence disease risk and screening strategies, potentially guiding precision medicine. Limitations include a small, non-diverse sample and observational data; lifestyle factors like stress and alcohol may also play a role in these transitions.
Multi-omics profiling across eight tissues in cachexia-bearing mice reveals a coordinated metabolic shift centered on one-carbon metabolism, linked to inflammation, glucose hypermetabolism and muscle atrophy; the pattern recapitulates across five cancer models and a humanized cachexia model, offering a systemic framework for tumor–host metabolic reprogramming and potential intervention targets.
Researchers have discovered a universal network of microbes that respond to cadaver decomposition, despite variations in climate, location, and season. The study used multi-omic data to reveal that a conserved interdomain soil microbial decomposer network assembles in response to mammalian remains, with evidence of increased metabolic efficiencies to process lipid- and protein-rich compounds. Key members of the microbial decomposer network are associated with various mammalian carrion, suggesting that they are not human-specific. The findings have implications for forensic science, agriculture, sustainability, and the human death care industry.
Scientists at the University of California San Diego School of Medicine have created a new map that shows the complex system of DNA damage response (DDR) in the human body. DDR is a network of cell-cycle checkpoints and DNA damage repair tools that help maintain the integrity of the genome and support normal functioning and health. The new map, which uses multi-omics and machine learning, shows a hierarchical organization of 605 proteins in 109 assemblies that captures canonical repair mechanisms and proposes new DDR-associated proteins linked to stress, transport, and chromatin functions within cells.