One-Time Psilocybin Dose May Prompt Lasting Brain Changes

A small study found that a single 25 mg dose of psilocybin in 28 volunteers produced detectable brain structural changes a month later via diffusion tensor imaging, with reduced diffusion along certain front-to-middle brain tracts, possibly due to fiber pruning or growth of unmyelinated fibers. An immediate surge in brain entropy during the experience correlated with deeper psychological insights and improved wellbeing a month afterward. Findings are preliminary given the small sample size and the indirect nature of DTI measurements, but they contribute to understanding how psychedelics might support mental health.