Psychedelics reshape brain networks, revealing an 'embedded' sense of self

A Nature study with 62 healthy adults shows psilocybin reorganizes brain networks across rest, mindfulness-like states, music, and cloud-watching, reducing the usual separation between self and world and revealing an 'embeddedness' signature that correlates with next-day positive changes. Using MRI/EEG and machine-learning mapped patterns, the research highlights context’s role in psychedelic experiences while noting limitations: participants were healthy volunteers, study was open-label and lacked a placebo, and results may not generalize to patients.