Rare Flemish Alzheimer's mutation uncovers a novel amyloid fold fueling vascular brain damage
TL;DR
A rare Flemish APP mutation in Alzheimer's alters the folding of amyloid-beta into a previously unseen Z-shaped filament that tends to accumulate around brain vessels, driving cerebral amyloid angiopathy and hemorrhage. Using cryo-EM, researchers show how loss of a methyl group at residue 21 promotes this vascular-prone fold, offering new targets for therapies and broader insight into Alzheimer’s pathology across its variants.
Topics:healthscience#alzheimers-disease#amyloid-beta#cerebral-amyloid-angiopathy#cryo-electron-microscopy#flemish-mutation#science
- Never-Before-Seen Type of Amyloid May Explain a Devastating Form of Alzheimer's ScienceAlert
- The Weekly Dose: New Findings in Alzheimer's, Cardiac Neurons, and Neurodegeneration | Newswise Newswise
- Atomic view of Alzheimer's disease peptide could inform new drugs Phys.org
- Alzheimer’s disease-linked Flemish APP mutation defines a distinct amyloid-β fold Nature
- Distinct amyloid-β filament fold in individuals with APP Flemish mutation Nature
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