Restoring Sleep in Alzheimer’s Model by Suppressing Brain Immune Cells

Researchers in a mouse model of Alzheimer's found microglia drive sleep loss; depleting most brain immune cells restored over two hours of nightly sleep and longer restorative sleep, even though amyloid plaques did not decrease, indicating microglial overactivity as a reversible sleep‑disruption driver. The work also points to portable EEG as a potential biomarker and explores repurposing existing drugs to calm microglia as possible therapies.