Somatic Mutations in B Cells May Drive Autoimmune Thyroid Disease
TL;DR Summary
Ultra-accurate sequencing shows somatic mutations in immune cells, especially B cells, can disable immune brakes and drive thyroid autoimmune diseases (Hashimoto’s and Graves’). This polyclonal evolution suggests a new mechanism beyond inheritance and hints at precision therapies that target mutant cell clones rather than broad immune suppression.
- Somatic Evolution Revealed as a Primary Driver of Autoimmune Disease Neuroscience News
- Cambridge scientists uncover secret of autoimmune diseases Cambridge University Hospitals
- Silent B-cell mutations may build for years before thyroid autoimmunity appears Medical Xpress
- Polyclonal Selection Drives Immune Checkpoint Mutations Bioengineer.org
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