Stellate-Cell Periostin Sparks Early Nerve Invasion in Pancreatic Cancer

Brazilian researchers identify periostin produced by pancreatic stellate cells as a key driver that remodels surrounding tissue, enabling pancreatic cancer cells to invade nerves early and spread, creating a dense desmoplastic microenvironment that hinders chemotherapy and immunotherapy; targeting periostin or the stellate cells offers a potential path for precision therapies to curb invasion and metastasis.