Stiffer Colon Tissues in Youth Linked to Early-Onset Colorectal Cancer

UT Dallas and UT Southwestern researchers found that colon tissue from younger colorectal cancer patients is abnormally stiff due to fibrotic collagen, in both tumor and nearby healthy tissue, and experiments with cells on stiff substrates and patient-derived organoids show stiffness promotes faster cancer growth; the study suggests biomechanical forces may contribute to rising cases of early-onset colorectal cancer and could guide future diagnosis and therapy, published in Advanced Science.