Tiny psilocybin study links intense trips to brain wiring changes

A small 28-participant study finds that after a 25 mg psilocybin dose, diffusion tensor imaging shows changes in water diffusion along neural fibers—especially in tracts linking the prefrontal cortex with other brain regions—with stronger trips associated with larger changes; about 70% of participants reported improved well-being 2–4 weeks later, suggesting psychedelic-induced brain plasticity, though results are exploratory and require replication in larger trials.