Two aging milestones revealed: the body shifts at 44 and 60, study finds

A Stanford-led study of 108 participants aged 25–75 found that aging is marked by two sharp molecular and microbial shifts, occurring precisely at ages 44 and 60. About 81% of the molecules analyzed changed in these windows, affecting cardiovascular and immune-system pathways and suggesting midlife is a critical period for aging. Researchers note lifestyle and genetics may influence these shifts and advise adopting healthier habits in one's 40s and 60s.