Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target

Researchers show cancer cells co-opt vitamin B2 (riboflavin) to power FSP1 and block ferroptosis, a form of cell death. Limiting B2 makes cancer cells more vulnerable, and a B2-mimic called roseoflavin can promote ferroptosis in lab cancer cells, hinting at a targeted therapy that could spare healthy cells. More work is needed to translate this into treatments and to explore ferroptosis' role in other diseases.