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Fsp1

All articles tagged with #fsp1

Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target
science1 day ago

Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target

Researchers show cancer cells co-opt vitamin B2 (riboflavin) to power FSP1 and block ferroptosis, a form of cell death. Limiting B2 makes cancer cells more vulnerable, and a B2-mimic called roseoflavin can promote ferroptosis in lab cancer cells, hinting at a targeted therapy that could spare healthy cells. More work is needed to translate this into treatments and to explore ferroptosis' role in other diseases.

via ScienceAlert|
#cancer#ferroptosis#fsp1
Vitamin B2 May Help Cancer Cells Avoid Ferroptotic Death
science2 months ago

Vitamin B2 May Help Cancer Cells Avoid Ferroptotic Death

Researchers find that riboflavin (vitamin B2) metabolism supports cancer cells' defenses against ferroptosis, an iron-driven form of cell death, via the FSP1 pathway. Lowering B2 metabolism could make tumors more susceptible to ferroptosis, and roseoflavin—an Anthrobacter-derived compound—triggers ferroptosis in cancer cells at low doses, suggesting a potential therapeutic approach, though specific inhibitors are not yet available.

via SciTechDaily|
#cancer#ferroptosis#fsp1
Lymph Node Environment Influences FSP1 Targeting and Ferroptosis in Melanoma and Lung Cancer
cancer-research6 months ago

Lymph Node Environment Influences FSP1 Targeting and Ferroptosis in Melanoma and Lung Cancer

The study reveals that the lymph node microenvironment promotes resistance to ferroptosis in metastasizing melanoma by downregulating GSH synthesis and upregulating FSP1, which localizes to lysosomes and provides a GPX4-independent protective mechanism. Oxygen levels and epigenetic regulation influence GPX4 stability and ferroptosis sensitivity, suggesting potential therapeutic strategies targeting FSP1 and GSH synthesis in LN metastases.

via Nature|
#cancer-research#ferroptosis#fsp1