All articles tagged with #fsp1
Researchers find that riboflavin (vitamin B2) metabolism supports cancer cells' defenses against ferroptosis, an iron-driven form of cell death, via the FSP1 pathway. Lowering B2 metabolism could make tumors more susceptible to ferroptosis, and roseoflavin—an Anthrobacter-derived compound—triggers ferroptosis in cancer cells at low doses, suggesting a potential therapeutic approach, though specific inhibitors are not yet available.
The study reveals that the lymph node microenvironment promotes resistance to ferroptosis in metastasizing melanoma by downregulating GSH synthesis and upregulating FSP1, which localizes to lysosomes and provides a GPX4-independent protective mechanism. Oxygen levels and epigenetic regulation influence GPX4 stability and ferroptosis sensitivity, suggesting potential therapeutic strategies targeting FSP1 and GSH synthesis in LN metastases.
Targeting FSP1 induces ferroptosis, a form of cell death, in lung cancer models, suggesting FSP1 as a promising therapeutic target for treating lung cancer by promoting tumor cell ferroptosis.