NAD Supplements and Aging: Promising biology, limited human proof

Nicotinamide adenine dinucleotide (NAD+) is a cellular coenzyme essential for energy production and DNA repair; NAD+ levels decline with age, prompting interest in supplements like nicotinamide riboside (NR) and NMN, and even IV NAD+. While some studies show NAD+ precursors can raise NAD+ in humans and IV NAD+ is used in certain contexts, there is no definitive evidence that NAD+ supplementation slows aging or extends lifespan. Experts say NAD+ boosting may support mitochondrial health within a broader longevity strategy, but it is not a standalone anti-aging miracle.