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New Pathway for β-Hydroxybutyrate in Cancer Cell Metabolism

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Source: Nature
New Pathway for β-Hydroxybutyrate in Cancer Cell Metabolism
Photo: Nature
TL;DR

The study reveals that cancer cells can produce cytosolic acetyl-CoA from β-hydroxybutyrate (β-OHB) via two pathways: the mitochondrial citrate-dependent route involving OXCT1 and a citrate-independent route involving AACS, supporting tumor growth especially under nutrient-limited conditions.

Topics:sciencebiology#b-hydroxybutyrate#biology#cancer-metabolism#cytosolic-acetyl-coa#ketone-pathways#tumor-growth
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An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells  Nature

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