Breakthrough in Cancer Treatment: Targeting Rogue DNA Circles
TL;DR
Stanford Medicine researchers have discovered that extrachromosomal DNA (ecDNA) circles, previously considered insignificant, play a crucial role in cancer development. Their studies, published in Nature, reveal that ecDNAs are prevalent in 17.1% of tumors and are linked to cancer progression and drug resistance. The research also highlights a novel inheritance mechanism of ecDNAs that challenges traditional genetic laws. A new therapy targeting these DNA circles is in clinical trials, offering hope for treating cancers with ecDNA-driven oncogene amplifications.
- Cracking the code of DNA circles in cancer: Scientists uncover potential therapy Medical Xpress
- Study raises hopes of treating aggressive cancers by zapping rogue DNA The Guardian
- Studies show how once-obscure DNA circles drive cancer, and maybe even how to stop them Endpoints News
- New Research Highlights How DNA Circles Drive Cancer Growth and Drug Resistance Inside Precision Medicine
- Mysterious circular DNA found in more than half of patients with certain types of cancer EL PAÍS USA
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