Buffer Optimization Enhances siRNA-Lipid Nanoparticle Stability
TL;DR
The article discusses how buffer optimization, specifically using mildly acidic, antioxidant-containing buffers like histidine, can significantly improve the room temperature stability of siRNA-lipid nanoparticles by mitigating lipid oxidation and RNA-lipid adduct formation, thereby extending shelf life and maintaining efficacy.
Topics:sciencescience-and-technology#drug-stability#formulation-optimization#lipid-nanoparticles#oxidation#science-and-technology#sirna
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