DNA Mimics GFP with Intricate 3D Architecture for New Functions.

Researchers have created a 3D architecture of a DNA mimic of green fluorescent protein (GFP) using lettuce RNA aptamers. The mimic, called Lettuce–DFHBI-1T, has a complex structure that includes a four-way junction and a G-quadruplex. The structure could be used to develop new RNA aptamers for imaging and detecting RNA in living cells.