Raygun: AI-driven, length-agnostic protein design that preserves function

Raygun is an autoencoder-based AI framework that encodes proteins as fixed-dimensional Gaussian distributions derived from protein language model embeddings, enabling rapid, single-shot generation of variants at any length with controlled substitutions and indels while preserving predicted structure and functional sites. It demonstrates miniaturization of fluorescent proteins and TurboID, enlargement of EGF with improved EGFR binding, and broad applicability to template-guided protein redesign, offering a faster alternative to diffusion-based de novo design.