ZMM Proteins and Holliday Junctions Ensure Accurate Meiotic Crossovers
TL;DR
The study reveals a feedback mechanism where double Holliday junctions (dHJs) and ZMM proteins work together to maintain the synaptonemal complex (SC) during meiosis, ensuring crossover formation and suppressing new DNA double-strand breaks, thereby coordinating meiotic progression and crossover assurance.
- Holliday junction–ZMM protein feedback enables meiotic crossover assurance Nature
- A Molecular Zipper and a DNA Link Team Up to Protect Fertility | Newswise Newswise
- Safeguarding Double Holliday Junctions Drives Meiotic Crossing Over Bioengineer.org
- Breakthrough Study Uncovers Mechanism of Chromosome Inheritance Across Generations Bioengineer.org
- Holliday Junction–ZMM Feedback Ensures Meiotic Crossovers Bioengineer.org
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