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Recombination

All articles tagged with #recombination

TV Snow Carried the Universe’s Oldest Light, Mostly Hidden in Plain Sight
science8 days ago

TV Snow Carried the Universe’s Oldest Light, Mostly Hidden in Plain Sight

A Space Daily explainer shows that some analog TV static came from the cosmic microwave background, the faint relic light from the early universe, though the exact share is device- and environment-dependent and often overstated as a fixed percent. Most of the snow was from the TV set itself and terrestrial noise, not the CMB. The CMB was discovered by Penzias and Wilson in 1964–65 and interpreted as Big Bang relic light by Dicke’s group; it dates to about 380,000 years after the Big Bang (recombination) and has cooled to ~2.7 kelvin today. With analog broadcasting retired, the historical “oldest light” is a memory, though the science remains.

via Space Daily|
#analog-television#cosmic-microwave-background#early-universe
Common regulatory variant in meiosis genes links crossover control to maternal aneuploidy risk
science4 months ago

Common regulatory variant in meiosis genes links crossover control to maternal aneuploidy risk

A large IVF-PGT analysis (139,416 embryos, 22,850 parental sets) maps crossovers and meiotic aneuploidy at scale and finds a common non-coding haplotype in SMC1B that associates with both lower maternal recombination and higher maternal meiotic aneuploidy, supported by functional assays and TWAS implicating C14orf39 and ubiquitin ligases CCNB1IP1/RNF212. SNP heritability for aneuploidy is negligible, suggesting environmental and rare-variant effects, while an inverse link between recombination rate and aneuploidy emerges. Evolutionary modelling suggests the risk allele is ancient and common, with complex fitness dynamics that can maintain it in populations. The work reveals a shared genetic basis for recombination and aneuploidy, with implications for fertility and genome evolution.

via Nature|
#aneuploidy#c14orf39#meiosis
health11 months ago

New COVID Variant NB.1.8.1 Sparks Global Surge Concerns

The Nimbus COVID-19 variant, a recombinant strain under monitoring, has been detected in multiple countries and may contribute to a summer surge of cases due to its increased transmissibility and immune evasion, though it is not yet linked to more severe illness. Current vaccines remain effective against it, but concerns about vaccine access and evolving guidelines could impact future protection efforts.

via Salon.com|
#covid-19#health#nimbus-variant
Insights into SARS-CoV-2 evolution, treatment, and prevalence in children.
science3 years ago

Insights into SARS-CoV-2 evolution, treatment, and prevalence in children.

This review article explores the mechanisms that generate genetic variation in SARS-CoV-2, underlying the within-host and population-level processes that underpin these events. The article examines the selective forces that likely drove the evolution of higher transmissibility and, in some cases, higher severity during the first year of the pandemic and the role of antigenic evolution during the second and third years, together with the implications of immune escape and reinfections, and the increasing evidence for and potential relevance of recombination. The article also evaluates uncertainties and outlines scenarios for the possible future evolutionary trajectories of SARS-CoV-2.

via Nature.com|
#evolution#mutation#recombination