
Genes help explain why obesity drugs work differently for people
Nature reports a study of nearly 28,000 23andMe users who used obesity drugs, linking a GLP-1 receptor gene variant to greater weight loss (about 0.76 kg per copy, ~1.5 kg for two copies) over a median of 8 months, and other variants to higher risk of side effects like nausea. Overall genetic effects on weight loss are modest, but associations with adverse effects are stronger; findings come from self-reported data and are not yet ready to guide clinical practice.













