Tag

Adipogenesis

All articles tagged with #adipogenesis

science1 month ago•5 min saved

Mitch protein switch makes human cells burn fats for energy, opening obesity research avenue

Weizmann Institute researchers showed that deleting MTCH2 (Mitch) in human cells triggers a hypermetabolic state: mitochondria burn more fuel, especially fats, while fat storage and fat-cell formation are reduced, shedding light on MTCH2 as a regulator of cellular energy and obesity—though translating this into safe human therapies will require extensive follow-up.

via ScienceAlert|

#adipogenesis #metabolism #mitch

science1 month ago•5 min saved

MTCH2 protein switch could boost fat burn while hindering new fat cells

Researchers identify MTCH2 ('Mitch') as a regulator of mitochondrial fusion; deleting Mitch in human cells fragments mitochondria and increases energy demand, boosting fat and carbohydrate breakdown and reducing new fat-cell formation. In mice, Mitch suppression in muscle improves endurance and protects against obesity. The findings point to Mitch as a potential target to enhance fat burning while limiting fat storage, though the work is early-stage and preclinical.

via ScienceDaily|

#adipogenesis #fat-metabolism #mitochondria