Tag

Amphotericin B

All articles tagged with #amphotericin b

science8 days ago•6 min saved

Gladiolin: Bacterial Antibiotic Shows Promise Against Drug-Resistant Fungal Infections

Researchers discovered gladiolin, a natural antibiotic from Burkholderia gladioli, can push the fungus Candida albicans from its invasive hyphal form back to the less harmful yeast form in lab tests. When used with amphotericin B, gladiolin and the drug together more effectively suppress fungal biofilms than either alone, suggesting a potential new approach to treating drug-resistant fungal infections, though extensive preclinical and clinical trials are still needed.

via ScienceAlert|

#amphotericin-b #antifungal-resistance #biofilms

health1 year ago•7 min saved

Recurrent Illness After Fungal Infection Baffle Doctors

Peter Redweik's severe illness after treatment for cryptococcal meningitis was caused by an autoimmune inflammatory response to dead fungus particles, not a recurrence of infection. Advanced diagnostics at the NIH helped identify this condition, leading to effective steroid treatment and recovery, despite lasting impairments.

via The Washington Post|

#amphotericin-b #cryptococcal-meningitis #fungal-infection

science-and-technology2 years ago•25 min saved

"Renal-Sparing Polyene Antifungal: A Breakthrough in Safe and Effective Fungal Treatment"

Researchers have developed a renal-sparing polyene antifungal by tuning the sterol extraction kinetics. The study focused on amphotericin B, a potent antifungal drug that can cause kidney damage. By modifying the drug's structure, the researchers were able to reduce its toxicity while maintaining its antifungal activity. This development is significant as fungal infections pose a growing threat, and the need for safer and more effective antifungal drugs is crucial.

via Nature.com|

#amphotericin-b #drug-development #fungal-infections