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Drug Development

All articles tagged with #drug development

Novo Taps Kallyope for Three Novel Obesity Programs
business21 days ago

Novo Taps Kallyope for Three Novel Obesity Programs

Novo Nordisk is expanding its obesity portfolio by acquiring three external programs from Kallyope: a lead peptide (K-554) that’s IND-ready, plus a follow-on small molecule for a novel target and a small-molecule receptor agonist. The deal adds non-incretin approaches to Novo’s obesity pipeline, with financial terms undisclosed. This follows Novo’s renewed push to diversify its pipeline alongside a separate $1.4 billion biobucks pact with Orbis Medicines, and amid recent setbacks in other programs such as ziltivekimab.

via Fierce Biotech|
#business#drug-development#kallyope
Metabolic double-play drug makes cancer burn sugar while starving fat
health1 month ago

Metabolic double-play drug makes cancer burn sugar while starving fat

A UT Austin team reports XJ-4-85, a small molecule that drives cancer cells to burn more sugar while blocking fat metabolism, creating a metabolic trap that slowed melanoma tumors in mice and killed various human cancer cells in vitro; it introduces electrophile-drug conjugates (EDCs) to reach intracellular targets, but human testing is still years away and safety/resistance remain unknown.

via thebrighterside.news|
#cancer#drug-development#drug-research
AI Slashes Time and Costs in Late-Stage Cancer Trials, Tufts Finds
healthcare1 month ago

AI Slashes Time and Costs in Late-Stage Cancer Trials, Tufts Finds

Tufts’ Center for the Study of Drug Development finds Medable’s AI monitoring agent can speed up late-stage (phase 2/3) cancer drug trials by about 10 weeks and cut direct operating costs by up to $5.6 million, with larger net benefits as the drug targets more cancers (potentially up to $565 million for 50 indications). The technology could become standard in 3–5 years, aiding enrollment, data locking, and earlier safety assessments, while still facing challenges like patient recruitment, consent, drug distribution, and the need for human verification.

via Axios|
#ai#clinical-trials#cost-savings
Biotech Prediction Bets on Trials Prompt Ethical Backlash
technology2 months ago

Biotech Prediction Bets on Trials Prompt Ethical Backlash

Kalshi’s plan to let users bet on the outcomes of clinical trials has drawn sharp ethical objections from researchers and patients who warn such markets could undermine trial integrity and patient welfare, even as Kalshi argues bets would reflect updated evidence and cut through hype. The controversy highlights broader concerns about gamifying lifesaving research and treating trials as speculative bets, rather than purely scientific endeavors.

via Futurism|
#biotech#clinical-trials#drug-development
Columbia Researchers Trace Alzheimer's Origins Inside Brain Cells, Paving Way for New Drugs
health2 months ago

Columbia Researchers Trace Alzheimer's Origins Inside Brain Cells, Paving Way for New Drugs

Columbia University researchers at the Alzheimer's Research Center are pinpointing where Alzheimer's starts by studying the brain cell's endosome, using mouse models and postmortem human brains to test whether correcting this defect can rescue brain cell function, with plans to translate findings into drugs through academia–industry collaboration over the coming years.

via ABC7 New York|
#alzheimers-disease#columbia-university#drug-development
Pancreatic cancer braces for post-daraxonrasib era
biotech2 months ago

Pancreatic cancer braces for post-daraxonrasib era

At a European pancreatic cancer conference, experts hailed the anticipated launch of daraxonrasib as a potential milestone that could reshape care, echoing the impact of checkpoint inhibitors. But they warned the new therapy would bring opportunities and challenges—from access and pricing to real-world effectiveness and how it will be integrated into standard treatment and combination strategies as data emerge.

via STAT|
#biotech#clinical-trials#daraxonrasib
Antarctic Sea Toxins Could Fuel a New Melanoma Drug
science3 months ago

Antarctic Sea Toxins Could Fuel a New Melanoma Drug

USF researchers collected Antarctic ascidians (sea squirts) and found toxins they produce can kill melanoma cells in mice, suggesting potential for a new melanoma treatment. Developing a safe, human-approved drug will require extensive lab work, animal studies, and synthetic production, with ongoing NSF-funded collaborations to reproduce the toxin and move toward trials while addressing ecological and safety concerns.

via The Guardian|
#antarctica#drug-development#marine-biology
FDA launches pilot to speed up early drug trials and bolster U.S. competitiveness
health-policy3 months ago

FDA launches pilot to speed up early drug trials and bolster U.S. competitiveness

The FDA announced a pilot to accelerate early-stage clinical trials, aiming to cut development time by six to 12 months, boost U.S.-based trials, and counter China, while seeking congressional support to establish a permanent, faster Investigational New Drug pathway in the 2027 budget; the effort follows advocacy by former FDA Commissioner Marty Makary.

via statnews.com|
#clinical-trials#drug-development#fda
Measles Returns, Sparking a Race for Therapeutics
health4 months ago

Measles Returns, Sparking a Race for Therapeutics

As U.S. measles outbreaks rise due to declining vaccination rates, researchers and biotech firms are racing to develop an approved antiviral or treatment, though none exists yet; the resurgence highlights the ongoing health and economic costs of low vaccination coverage and has spurred renewed interest in antiviral strategies and potential therapies under investigation by scientists.

via The New York Times|
#antivirals#drug-development#health