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Barretts Esophagus

All articles tagged with #barretts esophagus

health17 days ago•8 min saved

Hidden Onset: Barrett's Esophagus Likely Begins in Early Adulthood

Researchers using an esophagus-specific epigenetic clock analyzed UK cohorts and estimate that Barrett's esophagus often begins in early adulthood (roughly ages 20–30), decades before clinical diagnosis, creating a long premalignant window that may accumulate cancer-driving mutations and suggesting a shift toward personalized, continuous-risk screening rather than strict age cutoffs; however, broad screening of all GERD patients could lead to oversurveillance.

via Medscape|

#barretts-esophagus #epigenetic-clock #esophageal-adenocarcinoma

health4 months ago•9 min saved

Barrett’s Esophagus Emerges as the Universal Origin of Esophageal Cancer

A Cambridge-led study provides strong evidence that Barrett’s esophagus is the universal precursor to esophageal adenocarcinoma, even when visible signs are absent at diagnosis, by showing nearly identical DNA mutations across cancers. Researchers also identified biomarkers like TFF3 and REG4 that persist through disease, suggesting molecular screening could detect hidden pre-cancer risk and enable earlier intervention.

via SciTechDaily|

#barretts-esophagus #biomarkers #esophageal-cancer

health2 years ago•3 min saved

"Potential Link Between Daily Proton-Pump Inhibitor Use and Dementia/Neuropathy"

A retired individual with Barrett's esophagus and concerns about the effects of proton-pump inhibitors (PPIs) on dementia and neuropathy seeks advice from Dr. Keith Roach. While studies on the link between PPIs and atrial fibrillation (AFib) are inconclusive, the risk of esophageal cancer due to untreated acid reflux in Barrett's esophagus patients is a key concern. Dr. Roach recommends PPIs over H2 blockers for reducing the risk of esophageal cancer, despite known risks such as potential B12 deficiency and neuropathy. He emphasizes the importance of routine endoscopic surveillance and biopsies for early detection and treatment of any abnormal esophageal growth.

via OregonLive|

#barretts-esophagus #dementia #health