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Baxdrostat

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Aldosterone-Blocking Pill Shows Dual Benefit for CKD Patients with Hypertension
health17 days ago

Aldosterone-Blocking Pill Shows Dual Benefit for CKD Patients with Hypertension

An experimental aldosterone synthase inhibitor, baxdrostat, lowered systolic BP by 8.1 mm Hg more than placebo and cut urine albumin by 55% after 26 weeks in 192 CKD patients with uncontrolled hypertension on standard therapy, hinting at kidney and cardiovascular protection; however, hyperkalemia was more common (41% vs 5%), and serious adverse events were higher (9% vs 3%). Baxdrostat is not FDA-approved, and Phase 3 trials (including BaxHTN and Bax24) are under way, with exploring combinations like baxdrostat plus dapagliflozin.

via SciTechDaily|
#aldosterone#baxdrostat#chronic-kidney-disease
New Blood Pressure Drug Shows Promise as a Gamechanger in Hypertension Treatment
health8 months ago

New Blood Pressure Drug Shows Promise as a Gamechanger in Hypertension Treatment

A new drug, baxdrostat, has shown promising results in lowering blood pressure in patients with resistant hypertension, potentially reducing the risk of cardiovascular diseases. The phase III trial involving nearly 800 patients demonstrated significant blood pressure reductions, especially in difficult-to-treat cases, by blocking aldosterone production, a hormone that influences salt and water retention. This breakthrough could benefit up to half a billion people worldwide.

via Yahoo News Canada|
#baxdrostat#blood-pressure#clinical-trial
Revolutionary Blood Pressure Treatment Shows Promising Results
health8 months ago

Revolutionary Blood Pressure Treatment Shows Promising Results

A new drug, baxdrostat, has shown promising results in significantly lowering blood pressure in patients with resistant hypertension, potentially reducing cardiovascular risks. The Phase III trial led by UCL demonstrated that baxdrostat works by blocking aldosterone production, addressing a key cause of high blood pressure, and could help millions worldwide, including many in the UK.

via ScienceDaily|
#baxdrostat#blood-pressure#cardiovascular-risk
New Treatment Approach for Difficult High Blood Pressure
health9 months ago

New Treatment Approach for Difficult High Blood Pressure

A new experimental drug called Baxdrostat by AstraZeneca shows promise in treating resistant high blood pressure, especially for patients who do not respond well to existing medications. In a recent trial, Baxdrostat significantly lowered blood pressure in participants, potentially offering a new approach to reduce cardiovascular risks. The drug works by blocking aldosterone, a hormone that contributes to salt and water retention, and could become a key treatment for difficult-to-control hypertension if approved.

via yahoo.com|
#astrazeneca#baxdrostat#cardiovascular-risk
AstraZeneca and Baxdrostat unveil promising new treatments for resistant hypertension
health9 months ago

AstraZeneca and Baxdrostat unveil promising new treatments for resistant hypertension

AstraZeneca plans to seek regulatory approval for its experimental blood pressure drug, baxdrostat, by the end of the year, aiming for potential approval in 2026 in the US and EU. The drug targets the hormone aldosterone and has shown promising results in reducing systolic blood pressure, with peak sales expected to exceed $5 billion. A small percentage of patients experienced hyperkalaemia.

via Reuters|
#astrazeneca#baxdrostat#blood-pressure